What is Epithalon?
Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural peptide Epithalamin, produced by the pineal gland. Developed by Russian scientist Vladimir Khavinson, it is primarily studied for its ability to activate telomerase — the enzyme that rebuilds telomeres, the protective caps on chromosomes that shorten with each cell division and are considered a biomarker of aging.
Telomerase and Aging
Telomere length is strongly correlated with biological age. When telomeres become critically short, cells enter senescence or die. Research on Epithalon has shown it can increase telomerase activity in human somatic cells, potentially extending telomere length and cellular lifespan. Additional research suggests effects on melatonin production, antioxidant enzyme regulation, and circadian rhythm normalization.
Reconstitution
- 10 mg → 2 mL BAC water
- 20 mg → 4 mL BAC water
- 50 mg → 5 mL BAC water
Typical Protocols
5–10 mg injected subcutaneously or intramuscularly daily for 10–20 consecutive days, repeated 1–2 times per year. This cycling approach is based on the original Russian research protocols. Some protocols use twice-yearly 20-day cycles (January and July).
Educational purposes only. Most research is from Russian studies with limited Western peer review.