What is NAD+?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell. It plays a critical role in cellular energy production (converting nutrients to ATP in the mitochondria), DNA repair, gene expression regulation, and cellular signaling. NAD+ levels decline significantly with age — by age 50, levels can be 50% or less of what they were at age 20.
Why NAD+ is Different from Peptides
NAD+ is technically a coenzyme, not a peptide, but it is reconstituted and administered similarly to peptides and is popular in the same research community. It is available as injectable NAD+, IV infusion, nasal spray, and oral supplements (typically as NMN or NR precursors).
Reconstitution
NAD+ vials are significantly larger than most peptide vials due to the higher doses required.
- 100 mg → 5 mL BAC water (20 mg/mL)
- 250 mg → 5 mL BAC water (50 mg/mL)
- 500 mg → 10 mL BAC water (50 mg/mL)
- 1,000 mg → 10 mL BAC water (100 mg/mL)
Dosing and Administration
Subcutaneous: 50–250 mg, 2–3 times weekly. NAD+ injections are known to cause a stinging or burning sensation at the injection site. Inject slowly over 30–60 seconds and use a longer needle to go deeper into subcutaneous tissue. Some users report that warming the solution to body temperature reduces discomfort. IV infusion: 250–500 mg over 2–4 hours (clinical setting only).
Educational purposes only.